Workshop ANRS –HBV CURE

Du 16/05/2017 au 16/05/2017

Espace Saint Martin - 199Bis Rue Saint-Martin, 75003 Paris


Programme

Téléchargement du programme


8:15 am – WELCOME COFFEE

8:45 am – OPENING

Pr François Dabis – Director of the ANRS
Fabien Zoulim – Scientific Chair, ANRS HBV Cure Program

9:00 – 10:00 am – HBV CURE : CLINICAL PESPECTIVES

Chairs: Tarik Asselah, Fabrice Carrat
> 9:00::EASL clinical practice guidelines - Pietro Lampertico (Lyon)
> 9:20: New endpoints for novel HBV treatments - Geoffrey Dusheiko, (London)
> 9:40: Round table discussion

10.00 – 11.00 am – BIOMARKERS FOR FUNCTIONAL CURE

Chairs: Vincent Thibault, Stéphane Chevaliez
> 10.00: cccDNA standardization – Lena Allweiss, (Hamburg)
> 10.15: Serum HBcrAG – Barbara Testoni,(Lyon)
> 10.30: Circulating viral RNAs Florian Van Bommel (Leipzig)
> 10.45: Round table discussion

11:00 – 11:30 am– COFFEE BREAK

11.30 –12.25 am – NOVEL TARGETS AND ANTIVIRALS IN DEVELOPMENT

Chairs: Marc Bourlière, Michael Kann
> 11.30: Capsid assembly modulators entering in clinical evaluation – Fabien Zoulin (Lyon)
> 11.50: Pre-clinical and clinical date on siRNA – Massimo Levrero (Lyon)
> 12.10: Round table discussion

12.25 am – 1.00 pm – Role of the SMS5/6 complex and ND10 in HBV infection

Rudolf Beran (Foster City, USA)

1.00 – 2.15 pm – LUNCH BREAK AND POSTERS

2.15 – 3.10 pm – NOVEL STUDY MODELS FOR PATHOBIOLOGY AND DRUG DISCOVERY

Chairs: David Durantel, Mirjam Zeisel
> 2.15: An iPSplatform to study HBV-host interactome and support HBV drug discovery - Miriam Triyatni (Basel)
> 2.35: HBV infection in mouse models - Hélène Strick-Marchand, (Paris)
> 2.55: Round table discussion

3.10 – 4.05 pm – VIRAL GENOME INTEGRATION

Chairs: Massimo Levrero, Pierre Nahon
> 3.10: Impact on liver pathobiology and treatment – William Mason, (Philadelphia)
> 3.30: Impact on liver oncogenesis and cure of liver disease – Jessica Zucman-Rossi, (Paris)
> 3.50: Round table discussion

4.05 – 4:35 pm– COFFEE BREAK

4.35 – 5.15 pm – IMMUNOLOGY AND IMMUNOTHERAPY

Chairs: Lawrence Serfaty, Marie-Louise Michel
> 4.35: Mechanism of T cell exhaustion - Carlo Ferrari (Parma)
> 4.55: Immunotherapy of HBV: principles and clinical perspectives – Robert Thimme, (Freiburg)

5.15 – 5.45 pm – ROUND TABLE DISCUSSION

Chairs: Geoffrey Dusheiko, Fabien Zoulim
Reduction of viral antigen load and restoration of immune responses: who comes first? Is it the same in all patient groups? – Carlo Ferrari, Robert Thimme

5.45 pm – FAREWELL